The Most Important Causes of Death in Iranian Population; a Retrospective Cohort Study

Introduction: Health care providers and health policy managers need updated and valid information regarding causes of death (COD) for development the health care facilities, directing primary prevention, assigning funds, and promoting public health. The major causes of death and its burden have not been yet appropriately identified in Iran. Although several studies had been carried out in this area, most of them were local or performed in the past years and need to be update. Thus, the present study aimed to address the major causes of death and its burden in Iran. Methods: The present cross-sectional study was performed on graduate students and their families from February to March 2014. Through a two-stage random sampling procedure, data on 11315 subjects were obtained. The corresponding age of death, gender, and calendar year of death were inquired. All causes of death were categorized in nine groups including major cardiovascular disease, cancers, motor vehicle accidents, unintentional injuries, intentional injuries, stroke, lower respiratory infections, diabetes, and other reasons. Years of life lost (YLL) and person years of life lost were computed as the burden of diseases. Results: Totally, 11315 (50.4% male) subjects were studied. The results regarding death of relatives revealed that 360 deaths occurred (66.9% male). COD in 95 cases (26.4%) was cardiovascular diseases, 64 (17.8%) motor vehicle accidents, 41 (11.4%) cancers, 23 (6.4%) unintentional injuries, 22 (6.1%) intentional injuries, 10 (2.8%) stroke, 8 (2.2%) lower respiratory infections, 6 (1.8%) diabetes, and 91 (25.3%) other reasons. The average YLL due to all COD was 34.4±18.5. YLL for motor vehicle accidents and injuries (unintentional and intentional) were higher than cardiovascular diseases (p<0.001). In addition, person years of life lost for motor vehicle accidents were 2613.1 years. Cardiovascular diseases (2159.4 years), cancers (1321.0 years), and unintentional injuries (990.4 years) were in the next ranks. Conclusion: Based on the findings, it seems that cardiovascular diseases, motor vehicle accidents, cancers, intentional and unintentional injuries are the major causes of death in Iranian population. Most of years of life lost were due to motor vehicle accidents, cardiovascular diseases and cancers, intentional and unintentional injuries, respectively

The value of 18F-fluorodeoxyglucose positron emission tomography for prediction of treatment response in gastrointestinal stromal tumors: a systematic review and metaanalysis

Background: Early detection of response to treatment is critically important in gastrointestinal stromal tumors (GIST). Therefore, the present systematic review and meta-analysis assessed the value of 18f-fluorodeoxyglucose positron emission tomography (18FDG– PET) on prediction of therapeutic response of GIST patients to systemic treatments. Methods: The literature search was conducted using PubMed, SCOPUS, Cochrane, and Google Scholar databases, and review article references. Eligible articles were defined as studies included confirmed GIST patients who underwent 18FDG–PET as well as assessing the screening role of it. Results: Finally, 21 relevant articles were included. The analysis showed the pooled sensitivity and specificity of 18FDG–PET in evaluation of response to treatment of GIST patient were 0.90 (95% CI: 0.85–0.94; I 2 = 52.59, P = 0.001) and 0.62 (95% CI: 0.49–0.75; I 2 = 69.7, P = 0.001), respectively. In addition, the pooled prognostic odds ratio of 18FDG–PET for was 14.99 (95% CI, 6.42–34.99; I 2 = 100.0, P < 0.001). The Meta regression showed that sensitivity of 18FDG-PET was higher if the sample size of study was equal or more than 30 cases (sensitivity = 0.93; 95% CI: 0.89–0.97), when using PET/CT (sensitivity = 0.92; 95% CI: 0.89–0.97), and self-design criteria (sensitivity = 0.93; 95% CI: 0.87–1.0). Conclusion: The present meta-analysis showed 18FDG–PET has a significant value in predicting treatment response in GIST patients

Diagnostic Accuracy of Ultrasonography and Radiography in Detection of Pulmonary Contusion; a Systematic Review and Meta-Analysis

Introduction: Ultrasonography is currently being used as one of the diagnostic modalities in various medical emergencies for screening of trauma patients. The diagnostic value of this modality in detection of traumatic chest injuries has been evaluated by several studies but its diagnostic accuracy in diagnosis of pulmonary contusion is a matter of discussion. Therefore, the present study aimed to determine the diagnostic accuracy of ultrasonography and radiography in detection of pulmonary contusion through a systematic review and meta-analysis. Methods: An extended systematic search was performed by two reviewers in databases of Medline, EMBASE, ISI Web of Knowledge, Scopus, Cochrane Library, and ProQuest. They extracted the data and assessed the quality of the studies. After summarization of data into true positive, false positive, true negative, and false negative meta-analysis was carried out via a mixed-effects binary regression model. Further subgroup analysis was performed due to a significant heterogeneity between the studies. Results: 12 studies were included in this meta-analysis (1681 chest trauma patients, 76% male). Pooled sensitivity of ultrasonography in detection of pulmonary contusion was 0.92 (95% CI: 0.81-0.96; I2= 95.81, p&lt;0.001) and its pooled specificity was calculated to be 0.89 (95% CI: 0.85-0.93; I2 = 67.29, p&lt;0.001) while these figures for chest radiography were 0.44 (95% CI: 0.32-0.58; I2= 87.52, p&lt;0.001) and 0.98 (95% CI: 0.88-1.0; I2= 95.22, p&lt;0.001), respectively. Subgroup analysis showed that the sources of heterogeneity between the studies were sampling method, operator, frequency of the transducer, and sample size. Conclusion: Ultrasonography was found to be a better screening tool in detection of pulmonary contusion. Moreover, an ultrasonography performed by a radiologist / intensivist with 1-5MHz probe has a higher diagnostic value in identifying pulmonary contusions

Screening Performance Characteristic of Ultrasonography and Radiography in Detection of Pleural Effusion; a Meta-Analysis

Introduction: The role of ultrasonography in detection of pleural effusion has long been a subject of interest but controversial results have been reported. Accordingly, this study aims to conduct a systematic review of the available literature on diagnostic value of ultrasonography and radiography in detection of pleural effusion through a meta-analytic approach. Methods: An extended search was done in databases of Medline, EMBASE, ISI Web of Knowledge, Scopus, Cochrane Library, and ProQuest. Two reviewers independently extracted the data and assessed the quality of the articles. Meta-analysis was performed using a mixed-effects binary regression model. Finally, subgroup analysis was carried out in order to find the sources of heterogeneity between the included studies. Results: 12 studies were included in this meta-analysis (1554 subjects, 58.6% male). Pooled sensitivity of ultrasonography in detection of pleural effusion was 0.94 (95% CI: 0.88-0.97; I2= 84.23, p&lt;0.001) and its pooled specificity was calculated to be 0.98 (95% CI: 0.92-1.0; I2= 88.65, p&lt;0.001), while sensitivity and specificity of chest radiography were 0.51 (95% CI: 0.33-0.68; I2= 91.76, p&lt;0.001) and 0.91 (95% CI: 0.68-0.98; I2= 92.86, p&lt;0.001), respectively. Sensitivity of ultrasonography was found to be higher when the procedure was carried out by an intensivist or a radiologist using 5-10 MHz transducers. Conclusion: Chest ultrasonography, as a screening tool, has a higher diagnostic accuracy in identification of plural effusion compared to radiography. The sensitivity of this imaging modality was found to be higher when performed by a radiologist or an intensivist and using 5-10MHz probes

Application of Ultrasonography and Radiography in Detection of Hemothorax: a Systematic Review and Meta-Analysis

Introduction: Hemothorax is one of the most prevalent injuries caused by thoracic traumas. Early detection and treatment of this injury is of utmost importance in prognosis of the patient, but there are still controversial debates on the diagnostic value of imaging techniques in detection of hemothorax. Therefore, the present study aimed to evaluate the diagnostic value of chest ultrasonography and radiography in detection of hemothorax through a systematic review and meta-analysis. Methods: Two independent reviewers performed an extended systematic search in databases of Medline, EMBASE, ISI Web of Knowledge, Scopus, Cochrane Library, and ProQuest. Data were extract and quality of the relevant studies were assessed. The number of true positive, false positive, true negative and false negative cases were extracted and screening performance characteristics of two imaging techniques were calculated using a mixed-effects binary regression model. Results: Data from 12 studies were extracted and included in the meta-analysis (7361 patients, 77.1% male). Pooled sensitivity and specificity of ultrasonography in detection of hemothorax were 0.67 (95% CI: 0.41-0.86; I2= 68.38, p&lt;0.001) and 0.99 (95% CI: 0.95-1.0; I2= 88.16, p&lt;0.001), respectively. These measures for radiography were 0.54 (95% CI: 0.33-0.75; I2= 92.85, p&lt;0.001) and 0.99 (95% CI: 0.94-1.0; I2= 99.22, p&lt;0.001), respectively. Subgroup analysis found operator of the ultrasonography device, frequency of the transducer and sample size to be important sources of heterogeneity of included studies. Conclusion: The results of this study showed that although the sensitivity of ultrasonography in detection of hemothorax is relatively higher than radiography, but it is still at a moderate level (0.67%). The specificity of both imaging modalities were found to be at an excellent level in this regard. The screening characteristics of ultrasonography was found to be influenced of the operator and frequency of transducer

Comparison of Ultrasonography and Radiography in Detection of Thoracic Bone Fractures; a Systematic Review and Meta-Analysis

Introduction: The potential benefit of ultrasonography for detection of thoracic bone fractures has been proven in various surveys but no comprehensive conclusion has been drawn yet; therefore, the present study aimed to conduct a thorough meta-analytic systematic review on this subject. Methods: Two reviewers independently carried out a comprehensive systematic search in Medline, EMBASE, ISI Web of Knowledge, Scopus, Cochrane Library, and ProQuest databases. Data were summarized as true positive, false positive, true negative and false negative and were analyzed via STATA 11.0 software using a mixed-effects binary regression model. Sources of heterogeneity were further assessed through subgroup analysis. Results: Data on 1667 patients (807 subjects with and 860 cases without thoracic fractures), whose age ranged from 0 to 92 years, were extracted from 17 surveys. Pooled sensitivity and specificity of ultrasonography in detection of thoracic bone fractures were 0.97 (95% CI: 0.90-0.99; I2= 88.88, p&lt;0.001) and 0.94 (95% CI: 0.86-0.97; I2= 71.97, p&lt;0.001), respectively. The same measures for chest radiography were found to be 0.77 (95% CI: 0.56-0.90; I2= 97.76, p&lt;0.001) and 1.0 (95% CI: 0.91-1.00; I2= 97.24, p&lt;0.001), respectively. The sensitivity of ultrasonography was higher in detection of rib fractures, compared to fractures of sternum or clavicle (97% vs. 91%). Moreover, the sensitivity was found to be higher when the procedure was carried out by a radiologist in comparison to an emergency medicine specialist (96% vs. 90%). Conclusion: Base on the findings of the present meta-analysis, screening performance characteristic of ultrasonography in detection of thoracic bone fractures was found to be higher than radiography. However, these characteristics were more prominent in detection of rib fractures and in cases where was performed by a radiologist

Blood pressure percentiles by age and body mass index for adults

Since no comprehensive study has been conducted on blood pressure (BP) percentiles established upon nationally representative sample population of adults, the present study aimed to construct the blood pressure percentiles by age, sex and body mass index (BMI) of the subjects. Analyses were based on data collected in 2011 from 8,425 adults aged 25 to 69 years old. Data on demographic characteristics, anthropometric measurements, and blood pressure was recorded for each subject. Linear Regression analysis was used to assess the adjusted relationship of age-sex-specific standard deviation scores of BMI, height, and weight with blood pressure. Four separate models for systolic blood pressure (SBP) and diastolic blood pressure (DBP) of men and women were constructed for BP percentiles according to age and BMI. Blood pressure increased with the rise in BMI and weight, but showed a negative correlation with height. SBP and DBP rose steadily with increasing age, but the rise in SBP was greater than DBP. Overweight and obese population, seem to fall into the category of hypertensive. The findings of present study show that BP percentiles are steadily increased by age and BMI. In addition, most obese or overweight adults are hypertensive

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Investigating the psychoacoustic characteristics of absorbents used in common earmuffs: A laboratory study

Introduction: In addition to having auditory effects, sound also has nonauditory effects. Acoustic Annoyance is one of the nonauditory effects of sounds which are construed as psychoacoustic characteristics. The study at hand was undertaken to investigate the psychoacoustic characteristics of absorbents used in common earmuffs. Materials and Methods: In this study, four earmuffs prevalent in industries were used. The psychoacoustic characteristics of loudness and sharpness were measured and analyzed in sound levels of 75, 85, and 95 dB using an impedance tube and Va-Lab 4 software with and without absorbers. The results were analyzed with SPSS-26 software. Results: Results showed that the highest and the lowest increase in loudness were attributed to the EM-101 and the EM-104, respectively. In addition, with the increase in the sound level, the loudness increased. Furthermore, in 85 dB, there was no significant relationship between loudness and earmuff absorber only in the case of the earmuff EM-103. Furthermore, the highest and the lowest increase in sharpness were, respectively, attributed to the EM-101 and the EM-103. Only in the samples of EM-103 and EM-104 earmuffs at the level of 75 dB, there was no significant relationship between sharpness and earmuff absorber. Conclusion: Earmuffs used in industries showed different performances against the loudness and sharpness of the sound. In other words, the quality and the structure of earmuff absorber play noteworthy roles in decreasing the qualitative parameters of sound

Investigating the Relationship between the Prevalence of Musculoskeletal Disorders and Work Ability Index, Job Satisfaction, and Job Burnout in Isfahan Crystal and Glass Industry, Isfahan, Iran

Background: Musculoskeletal disorders are among the most important work-related diseases and hard working conditions in workshops and industries lead workers to experience these disorders. This study aimed to examine the prevalence of musculoskeletal disorders and its relationship with work ability index, job satisfaction, and job burnout among the workers of Isfahan Crystal and Glass Industry, Isfahan, Iran. Methods: This descriptive-analytic study was a cross-sectional one employing 251 workers from Isfahan Crystal and Glass Industry and was conducted in 2021. The data were collected through Cronell Musculoskeletal Disorders Questionnaire (CDMQ), Work Ability Index Questionnaire (WIA), Job Descriptive Index (JDI), and Copenhagen Burnout Inventory (CBI). The collected data were then submitted to SPSS to be analyzed through descriptive and inferential (Spearman correlation) statistics. The significance level was decided to be less than 0.05 (P < 0.05). Findings: 45.4% of the participants had musculoskeletal discomfort in at least one limb and 63.7% had high level of job satisfaction. On the other hand, the participants had high level of job burnout (mean = 81.55) and intermediate level of work ability (mean = 36). Further, there were no significant correlations between musculoskeletal disorders and job burnout, and between musculoskeletal disorders and work ability (P < 0.050), whereas there was a significant correlation between musculoskeletal disorders and job satisfaction (P < 0.050). Conclusion: Less than half of the participants had musculoskeletal disorders. The significant relationship between musculoskeletal disorders and job satisfaction was negative; the higher the level of job satisfaction, the lower the level of musculoskeletal disorders. Moreover, interventional and corrective measures are highly recommended to prevent these disorders